Fildena 120 mg, like other sildenafil-based medications, should not be taken with nitrate-based drugs. This is a critical safety concern due to the potential for a dangerous drop in blood pressure when these substances are combined. Why Nitrate-based Drugs and Fildena 120 mg Should Not Be Combined: Mechanism: Both Fildena 120 mg (which contains Sildenafil Citrate) and nitrate-based drugs (e.g., nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate) cause blood vessels to relax and widen (vasodilation). Sildenafil works by inhibiting PDE5, which also promotes vasodilation in the penile blood vessels. Nitrates work by increasing the production of nitric oxide, leading to vasodilation as well. Risk of Severe Hypotension: When used together, the vasodilation effects of both medications are intensified, leading to a significant drop in blood pressure (hypotension). This can cause symptoms such as dizziness, fainting, heart palpitations, or even life-threatening conditions like a heart attack or stroke. Who Should Avoid Taking Fildena 120 mg with Nitrates?: Individuals with Angina: People who use nitrate-based medications to manage chest pain (angina) due to coronary artery disease or other heart conditions must avoid taking Fildena 120 mg or any sildenafil-containing product. Heart Disease Patients: Men with a history of heart disease or conditions like heart failure, arrhythmias, or recent heart attack should also refrain from combining these medications due to the risks associated with low blood pressure and cardiovascular strain. Patients with Low Blood Pressure: Individuals who already have hypotension (low blood pressure) should avoid taking Fildena 120 mg with nitrates, as the combined effect could cause their blood pressure to drop dangerously low. Other Important Precautions: Medications: If you are currently taking nitrate-based drugs for any medical condition (e.g., angina, heart disease), discuss alternatives with your healthcare provider. Do not combine nitrates with Fildena 120 mg without medical advice. Emergency Situations: If you experience any symptoms of extremely low blood pressure, such as dizziness, fainting, or blurred vision while on Fildena 120 mg (especially after using a nitrate medication), seek immediate medical attention.